Immunoglobulin A Deficiency: Causes, Symptoms, and What You Can Do

When your body doesn’t make enough immunoglobulin A deficiency, a condition where the immune system fails to produce sufficient levels of IgA antibodies, leaving you vulnerable to infections. Also known as IgA deficiency, it’s the most common primary immune disorder, affecting about 1 in 600 people, yet many never know they have it until they get sick repeatedly.

This isn’t just about catching colds more often. recurrent infections, frequent sinus, ear, lung, and gut infections that don’t respond well to standard treatments are the red flag. People with this condition often battle bronchitis, pneumonia, or chronic diarrhea year after year. Some develop allergies or autoimmune diseases like celiac disease, because without IgA lining the gut and airways, the immune system starts attacking harmless substances—or even its own tissues.

antibody deficiency, a broader category that includes IgA deficiency and other immune system flaws where the body can’t make enough protective proteins isn’t something you outgrow. It’s usually lifelong. And while there’s no cure, knowing what’s happening helps you take control. You can’t fix the missing IgA, but you can reduce how often you get sick—through smarter hygiene, targeted supplements, avoiding unnecessary antibiotics, and working with a doctor who understands immune gaps.

Many people with IgA deficiency live normal lives, especially if they catch problems early. But others face years of misdiagnosis—told it’s stress, bad luck, or "just a weak immune system"—without ever getting the right test. A simple blood test can confirm it. Once you know, you can start preventing complications before they become serious.

Below, you’ll find real-world guides on how this condition connects to other health issues: from gut problems and skin reactions to how certain medications can make things worse or better. These aren’t theory pages—they’re practical tools from people who’ve been there. Whether you’re managing symptoms, helping a loved one, or just trying to understand why you’re always sick, this collection gives you the facts you need to move forward.